Application of trans ferulic acid in cardiovascular diseases

- Dec 20, 2018 -

ferulic acidThe trans-ferulic acid chemical synthesis technique uses a specific chemical synthesis route, and the trans-fertilic acid product produced does not contain a cis structure. The biggest difference between trans-ferulic acid and cis-ferulic acid is the elimination of the toxic side effects of cis-ferulic acid metabolism in the human body. The purity of the product is greater than 99.9%. The safety of ferulic acid has reached a qualitative leap.

Application in cardiovascular disease

1.Antithrombotic

Trans-ferulic acid can effectively inhibit blood agglutination, and can inhibit the release of serotonin, thromboxane-like substances and selectively inhibit the activity of thromboxane-synthesizing enzyme, so that the ratio of prostaglandin to thromboxane is increased, so it has anti- Thrombosis. Ferulic acid inhibits thromboxane release by several mechanisms: (1) selective inhibition of thromboxane synthase (2) and thromboxane antagonism (3) inhibition of arachidonic acid by inhibition of phospholipase A2 (PLA2) Free, thereby blocking the generation of TXA2 and the like. The inhibition of platelet aggregation by ferulic acid is also associated with its ability to increase C-AMP levels and inhibit phosphodiesterase activity.

2. Lowering blood fat

Rats were fed with 0.2% trans-ferulic acid in high-fat diet for 4 weeks. The serum cholesterol level of the mice was much lower than that of ferulic acid, indicating that ferulic acid can lower blood lipid levels. The mechanism of lipid-lowering of ferulic acid is considered to be competitive in inhibiting the activity of mevalonate-5-pyrophosphate dehydrogenase in the liver, that is, ferulic acid inhibits the synthesis of cholesterol in the liver.

Trans-ferulic acid can prevent and treat atherosclerosis by inhibiting lipid oxidation, lowering serum cholesterol content and anti-thrombosis, thereby achieving the purpose of treating coronary heart disease.

Application field

Trans-ferulic acid has an increasingly wide range of uses in the fields of medicine, food, and cosmetics. As a drug, it has anti-inflammatory, analgesic, anti-thrombosis, anti-ultraviolet radiation, anti-free radical and human immune function. It is mainly used for the treatment of diseases such as coronary heart disease, cerebrovascular disease, vasculitis, white blood cells and thrombocytopenia. In foods and cosmetics, it is mainly used as an antioxidant to produce basic raw materials for the treatment of cardiovascular and cerebrovascular diseases and leukopenia.