Ferulic acid is a functional phenolic acid ubiquitously present in plants. It is cross-linked with polysaccharides and lignin to form part of the plant cell wall. It is one of the most abundant phenolic acids in foods such as artichoke, eggplant and corn. It is also one of the active ingredients of commonly used traditional Chinese medicines such as Angelica, Cimicifuga and Chuanxiong. Ferulic acid is chemically structurally a phenolic hydroxy methoxylation product of caffeic acid 3-position. It has strong antioxidant activity and can scavenge various free radicals in the body, including hydrogen peroxide, superoxide radicals and hydroxyl radicals. , nitrous peroxide, etc.It has a strong protective effect on the cardiovascular system, nervous system, kidneys, etc. And it can be used clinically to treat diseases such as the respiratory system, cardiovascular system and urinary system.
From the study of pharmacological mechanism, ferulic acid can significantly inhibit the increase of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), thereby protecting the basic neurons in ischemic regions. Structure and function.Ferulic acid can also reduce the area of atherosclerosis caused by high cholesterol, so that the heart compliance and ejection function under ischemia and reperfusion are well protected. Ferulic acid also improves reserpine-induced neuropathic pain and abnormal behavior similar to depression by regulating the neurotransmitter monoaminergic system, the oxidative/antioxidant defense system, and the inflammatory apoptosis signaling pathway.
Natural ferulic acid can scavenge free radicals, promote the production of free radical scavenging enzymes, increase the activity of glutathione S-transferase and purine reductase, and inhibit tyrosinase activity to regulate human physiology. In addition, ferulic acid is widely used in the treatment of cardiovascular diseases as an active ingredient of various traditional Chinese medicines for promoting blood circulation and removing phlegm. Ferulic acid has a certain protective effect on erythrocyte hemolysis and can reduce the occurrence of serum autooxidation. It proves that it has a good protective effect on blood oxidative stress.