Ginsenoside is a commonly used botanical drug in cancer adjuvant therapy. Many cancer patients use ginsenoside in combination with chemoradiotherapy, targeted therapy, immunotherapy, surgeryto reduce toxicity, increase immunity, reduce recurrence.
There are many ginsenoside products on the market, but most people still don't know the difference between ginsenosides and ginsenosides. Let’s discuss the details as below:
Classification and difference of ginsenosides?
Ginsenosides are divided into two categories, one is the prototype ginsenoside and the other is the rare ginsenoside. Ginsenosides directly present in raw materials such as ginseng, American ginseng, and notoginseng are prototype ginsenosides, including ginsenosides Ra, Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, Rg1 and so on.
The prototype ginsenoside has low anticancer activity and poor bioavailability in the human body, which means that it is almost impossible for the human body to decompose and use the prototype ginsenoside. Scientists have converted the prototype ginsenosides into rare ginseng saponins by biological metabolism. The anti-cancer activity of rare ginseng saponins is significantly improved, and can also be absorbed and utilized by the human body. Therefore, currently used in the field of anti-cancer are all ginsenosides. Commonly used ginsenosides Rh2, Rg3, aPPD, Rk2, Rh3, aPPT, Rk1, Rg5, Rk3, Rh1, Rh3, Rh4 all belong to rare ginsenosides.
What is the total ginsenoside?
Ginsenoside saponins are a mixture of prototype ginsenosides crudely extracted from materials such as ginseng and American ginseng. It has not been isolated and has not been metabolized into rare ginsenosides. The main components are various prototype ginsenosides. The main components of total ginsenosides are Ra, Rb, Rc, Rd, Re, Rf, Rg and other prototype ginsenosides, so ginseng total saponins do not contain ginsenosides Rh2 and Rg3.
Since the anti-cancer activity of the prototype ginseng saponin is very low and difficult to be absorbed by the human body, the prototype ginsenoside has substantially no anti-cancer effect. So It’s basically not helpful for treating cancer if cancer patients taking ginseng total saponins.